People

Brian Chih-Hung Chiu, PhD

  • Professor of Public Health Sciences
    Professor of Family Medicine
  • Research and Scholarly Interests: Epigenetics, Health disparities, Liquid biopsy, Molecular epidemiology, Multiple Myeloma, Non-Hodgkin Lymphoma, Translational population research
  • Websites: Research Network Profile
  • Contact: bchiu@uchicago.edu
  • Graduate Program: Public Health Sciences

Dr. Chiu investigates the causes and outcomes of lymphoma and multiple myeloma in racial/ethnic and geographic diverse population using integrated modern molecular techniques and epidemiologic approaches. His main focus areas are: (1) studying modifiable nutritional, lifestyle, and environmental factors that are responsible for causing lymphoma and multiple myeloma, (2) identifying lifestyle, tumor, and treatment-related factors that influence survival, treatment response disparities, and outcomes of patients using cohorts of lymphoma and multiple myeloma patients as well as real world big data, and (3) developing novel epigenetics-based biomarkers for prognostication and management of patients using a liquid biopsy approach. He is also an active researcher in large international consortia, including the International Lymphoma Epidemiology Consortium (InterLymph), International Multiple Myeloma Consortium (now InterLymph-Myeloma Working Group) where he served as its chair in 2013, and the AsiaLymph.

Loss of 5-hydroxymethylcytosine expression is near-universal in B-cell lymphomas with variable mutations in epigenetic regulators.
Tanager KS, Yu J, Chiu BC, Carll TC, Tatarian AH, Riedell P, Smith S, Kline J, Venkataraman G. Loss of 5-hydroxymethylcytosine expression is near-universal in B-cell lymphomas with variable mutations in epigenetic regulators. Haematologica. 2022 Apr 01; 107(4):966-969.
PMID: 34911281

Investigation of the incidence trend of follicular lymphoma from 2008 to 2017 in Taiwan and the United States using population-based data.
Su YC, Chiu BC, Li HJ, Yang WC, Chen TY, Yeh SP, Wang MC, Huang WT, Lee MY, Lin SF. Investigation of the incidence trend of follicular lymphoma from 2008 to 2017 in Taiwan and the United States using population-based data. PLoS One. 2022; 17(3):e0265543.
PMID: 35298555

Loss of 5-hydroxymethylcytosine expression is nearuniversal in B-cell lymphomas with variable mutations in epigenetic regulators.
Tanager KS, Yu J, Chiu BC, Carll TC, Tatarian AH, Riedell P, Smith S, Kline J, Venkataraman G. Loss of 5-hydroxymethylcytosine expression is nearuniversal in B-cell lymphomas with variable mutations in epigenetic regulators. Haematologica. 2021 Dec 16.
PMID: 34911281

Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma.
Liu Z, Sarathkumara YD, Chan JKC, Kwong YL, Lam TH, Ip DKM, Chiu BC, Xu J, Su YC, Proietti C, Cooper MM, Yu KJ, Bassig B, Liang R, Hu W, Ji BT, Coghill AE, Pfeiffer RM, Hildesheim A, Rothman N, Doolan DL, Lan Q. Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Sci Rep. 2021 12 08; 11(1):23664.
PMID: 34880297

The association between physical health-related quality of life, physical functioning, and risk of contralateral breast cancer among older women.
Mukand NH, Ko NY, Nabulsi NA, Hubbard CC, Chiu BC, Hoskins KF, Calip GS. The association between physical health-related quality of life, physical functioning, and risk of contralateral breast cancer among older women. Breast Cancer. 2022 Mar; 29(2):287-295.
PMID: 34797467

Associations between frailty and cancer-specific mortality among older women with breast cancer.
Yan CH, Coleman C, Nabulsi NA, Chiu BC, Ko NY, Hoskins K, Calip GS. Associations between frailty and cancer-specific mortality among older women with breast cancer. Breast Cancer Res Treat. 2021 Oct; 189(3):769-779.
PMID: 34241741

Evaluation of Frequency of Administration of Intravenous Bisphosphonate and Recurrent Skeletal-Related Events in Patients With Multiple Myeloma.
Zhou J, Sweiss K, Han J, Ko NY, Patel PR, Chiu BC, Calip GS. Evaluation of Frequency of Administration of Intravenous Bisphosphonate and Recurrent Skeletal-Related Events in Patients With Multiple Myeloma. JAMA Netw Open. 2021 07 01; 4(7):e2118410.
PMID: 34313746

Disparities in diagnosis, treatment and survival between Black and White Parkinson patients.
Xie T, Liao C, Lee D, Yu H, Padmanaban M, Kang W, Johnson J, Alshaikh J, Yuen C, Burns M, Chiu BC. Disparities in diagnosis, treatment and survival between Black and White Parkinson patients. Parkinsonism Relat Disord. 2021 06; 87:7-12.
PMID: 33905958

Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma.
Chiu BC, Chen C, You Q, Chiu R, Venkataraman G, Zeng C, Zhang Z, Cui X, Smith SM, He C, Zhang W. Alterations of 5-hydroxymethylation in circulating cell-free DNA reflect molecular distinctions of subtypes of non-Hodgkin lymphoma. NPJ Genom Med. 2021 Feb 11; 6(1):11.
PMID: 33574286

Racial Disparities in Intravenous Bisphosphonate Use Among Older Patients With Multiple Myeloma Enrolled in Medicare.
Zhou J, Sweiss K, Nutescu EA, Han J, Patel PR, Ko NY, Lee TA, Chiu BC, Calip GS. Racial Disparities in Intravenous Bisphosphonate Use Among Older Patients With Multiple Myeloma Enrolled in Medicare. JCO Oncol Pract. 2021 03; 17(3):e294-e312.
PMID: 33449809

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Chair
International Multiple Myeloma Consortium
2013

Delta Omega Honorary Society in Public Health
Alpha Phi Chapter
2009

Outstanding alumni
University of Iowa College of Public Health
2006